MyHealthAvatar is built on the latest ICT technology with an aim of engaging public interest to achieve its targeted outcomes. In addition to data access, it is also an interface to access integrative models and analysis tools, utilizing resources already created by the VPH community. Overall, it contributes to individualized disease prediction and prevention and supports healthy lifestyles and independent living. It exerts a major influence on the reshaping of future healthcare in the handling of increased life expectancy and the ageing population in Europe. This complies with the priority and strategy of FP7 ICT for healthcare, and constitutes a preparatory action aiming at the grand challenge on a “Digital Patient”, which is currently the subject of a roadmap in the VPH community. MyHealthAvatar places a special emphasis on engaging the public. It has huge implications to the society both socially and economically. A personal avatar can potentially change the way we think, communicate and search for information. Meanwhile, the acceptance of the avatars by the public opens opportunities for many industrial sectors, leading to the reinforced leadership of European industry.